哲學博士（生物醫藥）課程 - Faculty of Health Sciences (FHS).pdf

PhD in Biomedical Sciences List of Potential Supervisors and Research Topic(s) Supervisor Research Topic(s) Prof. Chuxia DENG Oncogenes and tumor suppressor genes Stem cells, Cancer metastasis and Drug development Prof. Wei GE Genetic analysis of growth and reproduction in the zebrafish model Impacts of environmental endocrine-disrupting chemicals (EDCs) on reproduction and public health Zebrafish as a model for aging, human diseases and drug discovery Prof. Han-Ming SHEN Autophagy: Regulatory mechanisms and biological functions in cancer Mitophagy: Novel regulatory mechanisms Cancer metabolism: Targeting glucose metabolism in lung cancer Prof. Ren-He XU Mesenchymal stem cells: the development, heterogeneity, functions, and therapeutic application Prof. Guokai CHEN Metabolic regulation in stem cell maintenance and differentiation Novel mechanisms involved in cardiomyocyte differentiation and maturation Skin cell differentiation for regenerative medicine Endoderm differentiation for disease model Prof. Edwin CHEUNG Mechanism of gene regulation in cancer Single cell analysis Prof. Elaine Lai Han LEUNG Application of culturomic to investigate the anti-cancer treatment mechanism of TCM Investigation of cancer drug resistance mechanism and response predictive markers Role of gut microbiota in immunomodulation Prof. Kathy Qian LUO Circulating tumor cells and cancer metastasis Drug resistant and anti-cancer drug discovery Prof. Garry WONG Bioinformatics and Computational Biology of Aging related neurodegenerative diseases Prof. Yutao XIANG Psychiatric epidemiology Nursing research in psychiatry Evidence-based medicine COVID-19 related research in psychiatry Prof. Zhen YUAN Neuroscience and neuroimaging Biomedical Optics Optical Molecular Imaging and Cancer Nanomedicine Prof. Wenhua ZHENG Foxo and neuronal differentiation or new drugs development like artemisinin and metformin Drug development Neurodegenerative diseases The effect of Chinese medicine on tumor growth/metastasis and their underlying mechanisms Prof. William Chong Hang CHAO Prof. Yunlu DAI Structure and Function of Epigenetic Regulators Cancer nanomedicine Molecular imaging Drug delivery Prof. Lijun DI Mechanism study of cancer development and novel therapeutic strategy development Mechanism study of obesity, adipose tissue inflammation and insulin resistance Prof. Henry Hang Fai KWOK Antibody / Venom-based peptide targeted therapy for anti-cancer prototype drug discovery & development (Novel multi-specific antibody platforms for immunotherapy; Novel protein expression system for large scale production of hard-to-express venom-based protein drugs Biomarkers identification and validation based on the hallmarks of cancer Tackling cancer metastasis and drug resistance: from mechanism to therapy (Glyco-engineering to improve antibody quality attibutes for cancer therapy) PhD in Biomedical Sciences List of Potential Supervisors and Research Topic(s) Supervisor Prof. Leo Tsz On LEE Research Topic(s) Explore the role of GPCR signaling in cancer tumor microenvironment The using of RNA-dendrimer drugs in modulating cellular signaling cancer cells Prof. Gang LI Cancer epigenetics: from mechanism to therapy Signal transduction pathways in Epigenetics Prof. Tzu-Ming LIU In vivo microscopy and spectroscopy of tumor microenvironment Develop serum fluoroscope for the diagnosis of organ function Prof. Terence C.W. POON Proteomics/Protein/Biomarker-based research in precision medicine Bioinformatics-based research in precision medicine Prof. Joong Sup SHIM Exploiting synthetic lethality for cancer target discovery Prof. Kin Yip TAM Development of small molecule inhibitors targeting cancer metabolism or Alzheimer’s disease Combined use of metabolic inhibitors in lung cancer models Prof. Peng WANG Systems biology of cancer Algorithms for bio-medical big data Prof. Vivien Ya-Fan WANG Mechanism of gene regulation by NFkappaB and co-factors Prof. Chris Koon Ho WONG Transcription regulation of fungal metabolism and infection Identification of novel fungal secondary metabolites with anti-cancer and antibiotic properties Understanding the regulation of fungal spore dormancy and germination Prof. Ruiyu XIE Develop transplantable platform for stem-cell based diabetic therapy Molecular switches in endodermal lineage specification Epigentic regulation shapping tumor immune microenvironment in pancreas Prof. Hongjie ZHANG Deciphering the mRNP code in epithelial morphogenesis Post-translational modification in tubular organ formation Sphingosine 1-phosphate signaling in lumenal membrane integrity Prof. Xuanjun ZHANG Molecular Probes and Nanosensors Development of Phototheranostic Probes Prof. Qi ZHAO Nanomedicine and target drug delivery Antibody-based therapeutics against tumors Prof. Wa Kam CHANG How cells polarize during cell migration, with a focus on the cytoskeleton and nuclear envelope proteins How aging affects cell polarization and how cell polarization contributes to aging defects Deciphering the acting mechanism of aging factors on the cellular and whole genome levels Prof. Qiang CHEN Molecular mechanisms of cancer development Regulation of metabolic homeostasis Mechanisms of drug resistance in cancer Prof. Qihan CHEN Epigenetics: Novel DNA/RNA epigenetic modifications detection methods and applications Microbiology: Novel detection tools and therapy of bacteria and virus Molecular biology: Other novel molecular technologies for basic research and translational medicine Prof. Aifang CHENG Pathogenesis of neurodegenerative diseases Neuroprotective lead compounds discovery and drug repurposing Prof. Xiaofan DING Tumor hetereogeneity, evolution and immunity Multiomic data analysis and single-cell analysis Prof. Jiajie HOU Anti-cancer therapy and T cell signaling Liver-specific cancer immunoediting and combinatorial immunotherapy Prof. Kai MIAO Drivers and markers for tumor metastasis Gene therapy for cancer Applications of single cell related technology in cancer research Prof. Chen MING Detection of genetic variants affecting neurodegenerative diseases, especially Alzheimer’s disease PhD in Biomedical Sciences List of Potential Supervisors and Research Topic(s) Supervisor Research Topic(s) Prof. Ningyi SHAO Multi-omics integration of neurodegenerative diseases. Genetic differences of neurodegenerative diseases in multiple human populations. Novel mechanisms of neurodegenerative diseases in the single cell and spatial transcriptomic levels Study of lncRNA regulation in gender-biased diseases Integrated multi-omics analysis of tumor microevolution at the single cell level Mental health research Analysis of large clinical datasets for applied health sciences Health inequalities research Prof. Robert David SMITH